PIK3CA antibody

Description

Product Name PIK3CA antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were purified by affinity purification using immunogen.
Applications WB IHC
Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous level of total PIK3CA antibody.
Immunogen Type Recombinant Protein
Immunogen Description Recombinant protein of human PIK3CA.
Target Name PIK3CA
Alternative Names PIK3CA;MGC142161;MGC142163;PI3K;p110-alpha;
Accession No. Swiss-Prot#: P42336
NCBI Gene ID: 5290
SDS-PAGE MW 124kd
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20˚C

Application Details

Western blotting: 1:500 - 1:2000

Immunohistochemistry: 1:50 - 1:100

Images

Western blot analysis of extracts of various cell lines, using PIK3CA antibody.
Immunohistochemistry of paraffin-embedded rat kidney tissue using PIK3CA antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human prostate tissue using PIK3CA antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded human gastric cancer tissue using PIK3CA antibody at dilution of 1:100 (x40 lens).
Immunohistochemistry of paraffin-embedded mouse brain tissue using PIK3CA antibody at dilution of 1:100 (x40 lens).

Background

PIK3CA belongs to the PI3/PI4-kinase family. It phosphorylates PtdIns, PtdIns4P and PtdIns(4,5)P2 with a preference for PtdIns(4,5)P2. Defects in PIK3CA are associated with colorectal cancer (CRC). Defects in PIK3CA are associated with breast cancer. Defects in PIK3CA are associated with ovarian cancer. Defects in PIK3CA may underlie hepatocellular carcinoma (HCC). Defects in PIK3CA are a cause of keratosis seborrheic (KERSEB). The antibody is specific to PIK3CA.

Published Papers

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