TLR2 Antibody

Description

Product Name TLR2 Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antigen affinity purification.
Applications IHC
Species Reactivity Hu
Specificity The antibody detects endogenous levels of total TLR2 protein.
Immunogen Type Recombinant Protein
Immunogen Description Fusion protein corresponding to residues near the C terminal of human toll-like receptor 2
Target Name TLR2
Alternative Names TIL4; CD282
Accession No. Swiss-Prot#: O60603
NCBI Gene ID: 7097
Gene Accssion: BC033756
Concentration 0.3mg/ml
Formulation Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage Store at -20˚C

Application Details

Immunohistochemistry: 1:25-1:100

Images

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using #AB35576 at dilution 1/30.

Background

The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is expressed most abundantly in peripheral blood leukocytes, and mediates host response to Gram-positive bacteria and yeast via stimulation of NF-kappaB.?

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