HSPA8 Antibody

Description

Product Name HSPA8 Antibody
Host Species Rabbit
Clonality Polyclonal
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Applications WB
Species Reactivity Hu
Specificity The antibody detects endogenous levels of total HSPA8 protein.
Immunogen Type Peptide
Immunogen Description Synthesized peptide derived from internal of human HSPA8.
Target Name HSPA8
Alternative Names LAP-1;Heat shock 70 kDa protein 8; HSC70; HSP73;HSPA10
Accession No. Swiss-Prot: P11142
NCBI Gene ID: 3312
SDS-PAGE MW 72kd
Concentration 1.0mg/ml
Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20˚C

Application Details

Western blotting: 1:500~1:3000

Images

Western blot analysis of extracts from HuvEC, K562, Jurkat and HeLa cells, using HSPA8 antibody #AB35220.

Background

Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre-mRNA splicing. May have a scaffolding role in the spliceosome assembly as it contacts all other components of the core complex. Binds bacterial lipopolysaccharide (LPS) et mediates LPS-induced inflammatory response, including TNF secretion by monocytes.

Muraki T., Mol. Pharmacol. 58:1257-1263(2000).
Quadroni M., Submitted (MAR-2009).
Keith W.N., Submitted (JAN-2010).

Published Papers

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