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FKHRL1(Ab-253) AntibodyAB21171

Catalog No.	Package Size	Price
AB21171-1	50ul	$189.00
AB21171-2	100ul	$279.00
AB21171-4	25ul	$119.00

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Description

Product Name FKHRL1(Ab-253) Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Applications WB
Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous level of total FKHRL1 protein.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around aa.251~255(A-V-S-M-D) derived from Human FKHRL1.
Target Name FKHRL1
Alternative Names FOXO3A; FOXO2;
Accession No. Swiss-Prot: O43524
NCBI Protein: NP_001446.1
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 97kd
Western blotting: 1:500~1:1000

Images

Western blot analysis of extracts from 3T3, MCF and 293 cells using FKHRL1(Ab-253) Antibody #AB21171.

Background

Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'.

Brunet A., Bonni A., Zigmond M.J., Lin M.Z., Juo P., Hu L.S., Anderson M.J., Arden K.C., Blenis J., Greenberg M.E.Cell 96:857-868(1999)
Lehtinen M.K., Yuan Z., Boag P.R., Yang Y., Villen J., Becker E.B.E., DiBacco S., de la Iglesia N., Gygi S.P., Blackwell T.K., Bonni A.Cell 125:987-1001(2006)

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