Adiponectin Antibody

Description

Product Name Adiponectin Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Applications WB
Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous level of total Adiponectin protein.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around aa.235~239(T-G-F-L-L) derived from Human Adiponectin.
Target Name Adiponectin
Alternative Names ACDC; ADPN; APM1
Accession No. Swiss-Prot: Q15848
NCBI Protein: NP_001171271.1
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 27kd
Western blotting: 1:500~1:1000

Images

Western blot analysis of extracts from Rat and Mouse brain tissue using Adiponectin Antibody #AB21665.

Background

Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-a by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.

Yamauchi T., Kamon J., Waki H. Kadowaki T.Nat. Med. 7:941-946(2001)
Richards A.A., Stephens T., Charlton H.K. Mol. Endocrinol. 20:1673-1687(2006)

Published Papers

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