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NAC1 AntibodyAB21652

  Catalog No. Package Size Price
AB21652-1 50ul $189.00
AB21652-2 100ul $279.00
AB21652-4 25ul $119.00

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Description
  • Product Name NAC1 Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Applications WB
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous levels of total NAC1 protein.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around aa.519~523(A-G-P-S-A) derived from Human NAC1
  • Target Name NAC1
  • Alternative Names BEND8; NACC1; NAC-1; BTBD14B; FLJ37383
  • Accession No. Swiss-Prot: Q96RE7
    NCBI Protein: NP_443108.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 62kd
Western blotting: 1:500~1:1000

Images
  • NAC1 Antibody - Absci

    Western blot analysis of extracts from Rat and Mouse brain tissue using NAC1 Antibody #AB21652.

Background

Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines. "A BTB/POZ protein, NAC-1, is related to tumor recurrence and is essential for tumor growth and survival."
Nakayama K., Nakayama N., Davidson B.,et al.
Proc. Natl. Acad. Sci. U.S.A. 103:18739-18744(2006) "NAC-1 controls cell growth and survival by repressing transcription of Gadd45GIP1, a candidate tumor suppressor."
Nakayama K., Nakayama N., Wang T.-L., Shih I.-M. Cancer Res. 67:8058-8064(2007)

    Please let us know if you have published research using #AB21652 so that we can cite your reference.
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    Protocol
    Browsing historyclear
    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  


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