Doublecortin Antibody

Description

Product Name Doublecortin Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Applications WB
Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous level of total Doublecortin protein.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around aa.413~417( P-T-S-P-G) derived from Human Doublecortin.
Target Name Doublecortin
Alternative Names DCX; DC; DBCN
Accession No. Swiss-Prot: O43602
NCBI Protein: NP_000546.2
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 40-45kd
Western blotting: 1:500~1:1000

Images

Western blot analysis of extract from Molt-4 and Hela cells using Doublecortin Antibody #AB21630

Background

Seems to be required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCAMKL1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with LIS-1 of an overlapping, but distinct, signaling pathways that promote neuronal migration.

Des Portes V., Pinard J.-M., Billuart P. Chelly J.Cell 92:51-61(1998)
Pilz D.T., Matsumoto N., Minnerath S.R., Mills P. Hum. Mol. Genet. 7:2029-2037(1998)

Published Papers

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