ASH2L Antibody

Description

Product Name ASH2L Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Applications WB
Species Reactivity Hu
Specificity The antibody detects endogenous level of total ASH2L protein.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around aa.620~624(G-R-R-S-P) derived from Human ASH2L.
Target Name ASH2L
Alternative Names ASH2; Bre2; ASH2L1; ASH2L2;
Accession No. Swiss-Prot: Q9UBL3
NCBI Protein: NP_004665.2
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 65 80kd
Western blotting: 1:500~1:1000

Images

Western blot analysis of extract from HL-60 cells using ASH2L Antibody #AB21497

Background

Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis.

Wysocka J., Myers M.P., Laherty C.D., Eisenman R.N., Herr W.Genes Dev. 17:896-911(2003)
Patel A., Dharmarajan V., Vought V.E., Cosgrove M.S.J. Biol. Chem. 284:24242-24256(2009)

Published Papers

let us know

Customer Reviews and Rankings

No comment