Synapsin(phospho-Ser549) Antibody

Description

Product Name Synapsin(phospho-Ser549) Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Applications WB
Species Reactivity Hu Rt Ms
Specificity The antibody detects endogenous level of Synapsin only when phosphorylated at serine 549.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around phosphorylation site of serine 549(P-A-S(p)-P-S)derived from Rat Synapsin
Target Name Synapsin
Modification Phospho-Ser549
Alternative Names Syn-1; synapsin I;
Accession No. Swiss-Prot: O88935
NCBI Protein: NP_038708.3
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 78kd
Western blotting: 1:500~1:1000

Images

Western blot analysis of extract from rat brain and mouse brain tissue using Synapsin(phospho-Ser549) Antibody using #AB11568
Western blot analysis of extracts from Rat brain tissue or calf intestinal phosphatase (CIP), using Synapsin (phospho-Ser549) Antibody #AB11568.

Background

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level

Greengard, P. (1987) Mol Neurobiol 1, 81-119.
Hosaka, M. et al. (1999) Neuron 24, 377-87.

Published Papers

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