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Tau AntibodyAB21570

  Catalog No. Package Size Price
AB21570-1 50ul $189.00
AB21570-2 100ul $279.00
AB21570-4 25ul $119.00

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Description
  • Product Name Tau Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide
  • Applications WB
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous level of total Tau protein.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around aa. 725-729(T-G-S-I-D) derived from Rat Tau
  • Target Name Tau
  • Alternative Names MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
  • Accession No. Swiss-Prot: P19332
    NCBI Protein: NP_058908.2
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 48 62 78kd
Western blotting: 1:500~1:1000

Images
  • Tau Antibody - Absci

    Western blot analysis of extract from rat brain and mouse brain tissue using TAU Antibody #AB21570

Background
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Johnson , G.V. and Stoothoff , W.H. (2004) J. Cell Sci. 117, 5721-5729.
Hanger, D. P. et al. (1998) J. Neurochem. 71, 2465-2476.
Bramblett, G. T. et al. (1993) Neuron 10, 1089-1099.
    Please let us know if you have published research using #AB21570 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  


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