FAK(Ab-397) Antibody

Description

Product Name FAK(Ab-397) Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Applications WB
Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous levels of total FAK protein.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around aa. 395~399 (D-D-Y-A-E) derived from Human FAK.
Target Name FAK
Alternative Names FADK; PTK2; FAK1; FRNK; PTK2
Accession No. Swiss-Prot: Q05397
NCBI Protein: NP_005598.3
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 125kd
Western blotting: 1:500~1:1000

Images

Western blot analysis of extract from HepG2, 293, C6, HUVEC and HT29 cells using FAK(Ab-397) Antibody #AB21208

Background

Important regulator of cell cycle progression. Involved in G1 arrest. Potent inhibitor of cyclin E- and cyclin A-CDK2 complexes. Positive regulator of cyclin D-dependent kinases such as CDK4. Regulated by phosphorylation and degradation events.

von Sengbusch A, et al. (2005) Am J Pathol ; 166(2): 585-596
Fornaro M, et al. (2000) Mol Biol Cell ; 11(7): 2235-2249
Zhang X, et al. (1999) Proc Natl Acad Sci U S A; 96(16): 9021-9026.

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