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cofilin1/cofilin2(Ab-88) AntibodyAB21507

  Catalog No. Package Size Price
AB21507-1 50ul $189.00
AB21507-2 100ul $279.00
AB21507-4 25ul $119.00

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Description
  • Product Name cofilin1/cofilin2(Ab-88) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Applications WB IHC IF
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous level of total cofilin1/cofilin2 protein.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around aa. 86~90 (A-T-Y-E-T) derived from Human cofilin1/cofilin2.
  • Target Name cofilin1/cofilin2
  • Alternative Names Cofilin; non-muscle isoform 18 kDa phosphoprotein;
  • Accession No. Swiss-Prot: P23528 Q9Y281
    NCBI Protein: NP_005498.1 NP_068733.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 19kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200

Images
  • cofilin1/cofilin2(Ab-88) Antibody - Absci

    Western blot analysis of extracts from MDA cells using cofilin1/cofilin2(Ab-88) Antibody #AB21507.

  • cofilin1/cofilin2(Ab-88) Antibody - Absci

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using cofilin1/cofilin2(Ab-88) Antibody #AB21507(left) or the same antibody preincubated with blocking peptide(right).

  • cofilin1/cofilin2(Ab-88) Antibody - Absci

    Immunofluorescence staining of methanol-fixed Hela cells using cofilin1/cofilin2(Ab-88) Antibody #AB21507.

Background

Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods.

Carlier, M. et al. (1999) J. Biol. Chem. 274, 33827-33830.
Arber, S. et al. (1998) Nature 393, 805-809.
Yang, N. et al. (1998) Nature 393, 809-812.

    Please let us know if you have published research using #AB21507 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  


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