CRY1 Antibody

Description

Product Name CRY1 Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Applications WB
Species Reactivity Mouse
Specificity The antibody detects endogenous level of total CRY1 protein.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around aa.551~555 (S-Q-G-S-G) derived from Human CRY1.
Target Name CRY1
Alternative Names PHLL1
Accession No. Swiss-Prot: Q16526
NCBI Protein: NP_031797.1
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 60kd
Western blotting: 1:500~1:1000

Images

Western blot analysis of extracts from mouse brain tissue using CRY1 antibody #AB21414.
Western blot analysis of extracts from 293T cells and Rat testis tissue using CRY1 Antibody #AB21414.

Background

Blue light-dependent regulator of the circadian feedback loop. Inhibits CLOCK|NPAS2-ARNTL E box-mediated transcription. Acts, in conjunction with CRY2, in maintaining period length and circadian rhythmicity. Has no photolyase activity. Capable of translocating circadian clock core proteins such as PER proteins to the nucleus. May inhibit CLOCK|NPAS2-ARNTL transcriptional activity through stabilizing the unphosphorylated form of ARNTL

Morioka N,et al. (2010) J Pharmacol Sci.113(3):234-45.
Fonseca F,et al. (2010) Mol Diagn Ther.14(3):171-8.
Stratmann M,et al.(2010) Genes Dev.24(12):1317-28.

Published Papers

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