NRF1 Antibody

Description

Product Name NRF1 Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were purified by affinity purification using immunogen.
Applications WB
Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous level of total NRF1 protein.
Immunogen Type Recombinant Protein
Immunogen Description Recombinant protein of human NRF1.
Target Name NRF1
Alternative Names ALPHA-PAL;
Accession No. Swiss-Prot:Q16656
NCBI Gene ID:4899
SDS-PAGE MW 53KD
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20˚C

Application Details

Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:200

Images

Western blot analysis of extracts of various cell lines, using NRF1 antibody.

Background

This gene encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized. Additional variants encoding different protein isoforms have been described but they have not been fully characterized. Confusion has occurred in bibliographic databases due to the shared symbol of NRF1 for this gene and for "nuclear factor (erythroid-derived 2)-like 1" which has an official symbol of NFE2L1.

Published Papers

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