GluR2 (Ab-880) antibody

Description

Product Name GluR2 (Ab-880) antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Applications WB
Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous level of total Glutamate receptor 2 (Precursor) protein.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around aa.878~882 (I-E-S-V-K) derived from Human Glutamate receptor 2.
Target Name GluR2
Alternative Names GRIA2; GluR-2; GluR-B; GluR-K2; AMPA 2
Accession No. Swiss-Prot: P42262
NCBI Protein: NP_000817.2
SDS-PAGE MW 100kd
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 100kd
Western blotting: 1:500~1:1000

Images

Western blot analysis of extracts from mouse brain and rat brain tissue using GluR2 (Ab-880) antibody #AB21284.

Background

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.

Cull-Candy, S. et al. (2006) Curr. Opin. Neurobiol. 16, 288-297.
Hanley JG, et al. (2002) Neuron. 34(1): 53-67

Published Papers

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