Gab1(Ab-627) Antibody

Description

Product Name Gab1(Ab-627) Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Applications WB
Species Reactivity Hu Ms
Specificity The antibody detects endogenous level of total Gab1 protein.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around aa.625~629 (V-E-Y-L-D) derived from Human Gab1.
Target Name Gab1
Alternative Names Growth factor receptor bound protein 2-associated protein 1
Accession No. Swiss-Prot: Q13480
NCBI Protein: NP_002030.2
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 110kd
Western blotting: 1:500~1:1000

Images

Western blot analysis of extracts from A431 and MCF cells using Gab1 (Ab-627) Antibody #AB21283.

Background

The protein encoded by Gab1 is a member of the IRS1-like multisubstrate docking protein family. It is an important mediator of branching tubulogenesis and plays a central role in cellular growth response, transformation and apoptosis. Two transcript variants encoding different isoforms have been found for this gene.

Anders Kallin, et al. (2004) J. Biol. Chem; 279: 17897 - 17904.
Hideto Kameda, et al. (2001) Cell Growth Differ; 12: 307.
Masaki Osawa, et al. (2002) J. Cell Biol; 158: 773.

Published Papers

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