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PKR(Ab-451) AntibodyAB21282

  Catalog No. Package Size Price
AB21282-1 50ul $189.00
AB21282-2 100ul $279.00
AB21282-4 25ul $119.00

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Description
  • Product Name PKR(Ab-451) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Applications IHC IF
  • Species Reactivity Hu
  • Specificity The antibody detects endogenous level of total PKR protein.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around aa.449~453 (K-G-T-L-R) derived from Human PKR.
  • Target Name PKR
  • Alternative Names ADRB2; E2AK2; EIF2AK2; EIF2aK; PRKR
  • Accession No. Swiss-Prot: P19525
    NCBI Protein: NP_001129123.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 68kd
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200

Images
  • PKR(Ab-451) Antibody - Absci

    Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using PKR(Ab-451) Antibody #AB21282(left) or the same antibody preincubated with blocking peptide(right).

  • PKR(Ab-451) Antibody - Absci

    Immunofluorescence staining of methanol-fixed Hela cells using PKR(Ab-451) Antibody #AB21282.

Background

Following activation by double-stranded RNA in the presence of ATP, the kinase becomes autophosphorylated and can catalyze the phosphorylation of the translation initiation factor EIF2S1, which leads to an inhibition of the initiation of protein synthesis. Double-stranded RNA is generated during the course of a viral infection.

Ingrid K. Ruf, et,al. (2005) J. Virol ; 79: 14562 - 14569.
Christy M. Hebner,et,al. (2006) J. Gen. Virol ; 87: 3183 - 3193.
Rika van Huizen, et,al. (2003) J. Biol. Chem ; 278: 15558 - 15564.

    Please let us know if you have published research using #AB21282 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  


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