Integrin b3(Ab-785) Antibody

Description

Product Name Integrin b3(Ab-785) Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Applications WB
Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous level of total Integrin b3 protein.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around aa.783~787 (I-T-Y-R-G) derived from Human Integrin B3/ITGB3.
Target Name Integrin b3
Alternative Names CD61 antigen; GP3A; GPIIIa; ITB3; Platelet membrane glycoprotein IIIa
Accession No. Swiss-Prot: P05106
NCBI Protein: NP_000203.2
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 110kd
Western blotting: 1:500~1:1000

Images

Western blot analysis of extracts from HL60 and HT29 cells using Integrin b3(Ab-785) Antibody #AB21274.

Background

The Itg-Beta3 gene encodes the beta subunit of the platelet membrane adhesive protein receptor complex Itg-Beta3 protein, which belongs to the Integrin class of cell adhesion molecule receptors that share a common heterotrimeric structure with a and Beta subunits. It is a common Beta subunit of the platelet complex and of two other Integrins (Fibronectin and Vitronectin Receptors), which have distinct a subunits. Itg-Beta3 has been implicated in a wide variety of functions, including platelet aggregation and thrombosis and implantation, placentation, angiogenesis, bone remodeling, and tumor progression. Glanzmann Thrombasthenia can result from defects in the genes for either the Itg-a2B or the Itg-Beta3 subunit

Sujoy Bhattacharya, et al. (2006) Biochem J. August 1; 397(Pt 3): 437

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