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eIF2a(Ab-51) AntibodyAB21271

  Catalog No. Package Size Price
AB21271-1 50ul $189.00
AB21271-2 100ul $279.00

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  • Product Name eIF2a(Ab-51) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Applications WB IHC IF
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous level of total eIF2a protein.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around aa.49~53 (E-L-S-R-R) derived from Human eIF2a.
  • Target Name eIF2a
  • Alternative Names Eukaryotic translation initiation factor 2 subunit alpha; EIF-2A;
  • Accession No. Swiss-Prot: P05198
    NCBI Protein: NP_004085.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 38kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200

  • eIF2a(Ab-51) Antibody - Absci

    Western blot analysis of extracts from 3T3, Hela and C6 cells using eIF2a(Ab-51) Antibody #AB21271.

  • eIF2a(Ab-51) Antibody - Absci

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using eIF2a(Ab-51) Antibody #AB21271(left) or the same antibody preincubated with blocking peptide(right).

  • eIF2a(Ab-51) Antibody - Absci

    Immunofluorescence staining of methanol-fixed Hela cells using eIF2a(Ab-51) Antibody #AB21271.


Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Xavier Saelens, et,al. (2001) J. Biol. Chem; 276: 41620 - 41628.
Hong-Li Wu, Yu-Hua Li, Yan-Hua Lin, et al. (2008) Salvianolic acid B protects human endothelial cells from oxidative stress damage: a possible protective role of glucose-regulated protein 78 induction Cardiovasc Res doi:10.1093/cvr/cvn262
This article references the use of the #21271.

    Please let us know if you have published research using #AB21271 so that we can cite your reference.
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    Browsing historyclear
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  

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