NPPA Antibody

Description

Product Name NPPA Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were purified by affinity purification using immunogen.
Applications WB IHC
Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous level of total NPPA protein.
Immunogen Type Recombinant Protein
Immunogen Description Recombinant protein of human NPPA.
Target Name NPPA
Alternative Names ANF; ANP; PND; ATFB6; CDD-ANF
Accession No. Swiss-Prot:P01160
NCBI Gene ID:4878
SDS-PAGE MW 17KD
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20˚C

Application Details

Western blotting: 1:500 - 1:2000
Immunohistochemistry: 1:50 - 1:100

Images

Western blot analysis of extracts of PC-3 cell lines, using NPPA antibody.
Immunohistochemistry of paraffin-embedded human rectal cancer using NPPA antibody at dilution of 1:200 (x400 lens).

Background

The protein encoded by this gene belongs to the natriuretic peptide family. Natriuretic peptides are implicated in the control of extracellular fluid volume and electrolyte homeostasis. This protein is synthesized as a large precursor (containing a signal peptide), which is processed to release a peptide from the N-terminus with similarity to vasoactive peptide, cardiodilatin, and another peptide from the C-terminus with natriuretic-diuretic activity. Mutations in this gene have been associated with atrial fibrillation familial type 6.

Published Papers

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