Dab1(Ab-232) Antibody

Description

Product Name Dab1(Ab-232) Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Applications IHC
Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous level of total Dab1 protein.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around aa.230~234 (G-V-Y-D-V) derived from Human Dab1.
Target Name Dab1
Alternative Names Disabled homolog 1
Accession No. Swiss-Prot: O75553
NCBI Protein: NP_066566.3
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 80kd
Immunohistochemistry: 1:50~1:100

Images

Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Dab1(Ab-232) Antibody #AB21251(left) or the same antibody preincubated with blocking peptide(right).

Background

The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. This gene is similar to disabled-1, and the protein encoded by this gene is thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Alternatively spliced transcript variants of this gene have been reported, but their full length nature has not been determined.

Kelian Chen, et,al. (2003) J. Cell Sci ; 117: 4527 - 4536.
Vera Strasser, et,al. (2004) Mol. Cell. Biol ; 24: 1378 - 1386.
Izhar Ben-Shlomo, et,al. (2003) Sci. STKE ; 2003: 9.
H. M. Kim, et,al. (2002) PNAS ; 99: 4020.

Published Papers

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