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4E-BP1(Ab-46) AntibodyAB21216

  Catalog No. Package Size Price
AB21216-1 50ul $189.00
AB21216-2 100ul $279.00
AB21216-4 25ul $119.00

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  • Product Name 4E-BP1(Ab-46) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Applications WB IHC IF
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous level of total 4E-BP1 protein.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around aa.44~48 (S-T-T-P-G) derived from Human 4E-BP1.
  • Target Name 4E-BP1
  • Alternative Names EIF4EBP1; PHAS-1;
  • Accession No. Swiss-Prot: Q13541
    NCBI Protein: NP_004086.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 18kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
Immunofluorescence: 1:100~1:200

  • 4E-BP1(Ab-46) Antibody - Absci

    Western blot analysis of extracts from 293 and HepG2 cells using 4E-BP1 (Ab-46) Antibody #AB21216.

  • 4E-BP1(Ab-46) Antibody - Absci

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using 4E-BP1 (Ab-46) Antibody #AB21216 (left) or the same antibody preincubated with blocking peptide (right).

  • 4E-BP1(Ab-46) Antibody - Absci

    Immunofluorescence staining of methanol-fixed Hela cells using 4E-BP1 (Ab-46) Antibody #AB21216.


4E-BP1 encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation.

Gingras AC, et al. (1998) Genes Dev 12(4): 502-513.
Brugarolas J, et al. (2004) Genes Dev 18(23): 2893-2904.
Kumar V, et al. (2000) EMBO J 19(5): 1087-1097.
Moody CA, et al. (2005) J Virol 79(9): 5499-5506.
Burnett PE, et al. (1998) Proc Natl Acad Sci U S A 95(4): 1432-1437.

    Please let us know if you have published research using #AB21216 so that we can cite your reference.
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    Browsing historyclear
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  

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