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Smad2 (Phospho-Ser465) AntibodyAB11838

  Catalog No. Package Size Price
AB11838-1 50ul $189.00
AB11838-2 100ul $279.00

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Description
  • Product Name Smad2 (Phospho-Ser465) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • Applications WB
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous levels of Smad2 only when phosphorylated at serine 465.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around phosphorylation site of Serine 465(C-S-S(p)-M-S) derived from Human Smad2.
  • Target Name Smad2
  • Modification Phospho-Ser465
  • Alternative Names hMAD-2; JV18; JV18-1; MAD; hSMAD2
  • Accession No. Swiss-Prot#: Q15796;
    NCBI Gene#: 4087;
    NCBI Protein#: NP_001003652.1.
  • SDS-PAGE MW 52kd
  • Concentration 1.0mg/ml
  • Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20˚C/1 year
Application Details

Western blotting: 1:500~1:1000

Images
  • Smad2 (Phospho-Ser465) Antibody - Absci

    Western blot analysis of extracts from K562 cells using Smad2 (Phospho-Ser465) Antibody #AB11838.The lane on the right is treated with the antigen-specific peptide.

Background

Transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase. SMAD2 is a receptor-regulated SMAD (R-SMAD). May act as a tumor suppressor in colorectal carcinoma.

Riggins G.J., Nat. Genet. 13:347-349(1996).
Zhang Y., Nature 383:168-172(1996).
Eppert K., Cell 86:543-552(1996).

    Please let us know if you have published research using #AB11838 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  


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