FGFR4 (Phospho-Tyr642) Antibody

Description

Product Name FGFR4 (Phospho-Tyr642) Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Applications WB
Species Reactivity Hu
Specificity The antibody detects endogenous levels of FGFR4 only when phosphorylated at tyrosine 642.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around phosphorylation site of tyrosine 642(I-D-Y(p)-Y-K) derived from Human FGFR4 .
Target Name FGFR4
Modification Phospho-Tyr642
Alternative Names FGFR-4; CD_antigen=CD334; Fibroblast growth factor receptor 4; EC=2.7.10.1;
Accession No. Swiss-Prot#: P22455;
NCBI Gene#: 2264;
NCBI Protein#: NP_002002.3.
SDS-PAGE MW 90kd
Concentration 1.0mg/ml
Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20˚C/1 year

Application Details

Western blotting: 1:500~1:1000

Images

Western blot analysis of extracts from JK cells (Lane 2), using FGFR4 (Phospho-Tyr642) Antibody #AB11836. The lane on the left is treated with antigen-specific peptide.

Background

Receptor for acidic fibroblast growth factor. Does not bind to basic fibroblast growth factor. Binds FGF19.

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Ron D., J. Biol. Chem. 268:5388-5394(1993) [PubMed: 7680645].
Takaishi S.,Biochem. Biophys. Res. Commun. 267:658-662(2000) [PubMed: 10631118].

Published Papers

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