TAL-1 (Phospho-Ser122) Antibody

Description

Product Name TAL-1 (Phospho-Ser122) Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Applications WB
Species Reactivity Hu Ms
Specificity The antibody detects endogenous levels of TAL-1 only when phosphorylated at serine 122.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around phosphorylation site of Serine 122(Q-L-S(p)-P-P) derived from Human TAL-1.
Target Name TAL-1
Modification Phospho-Ser122
Alternative Names SCL; TAL1; TCL5;
Accession No. Swiss-Prot#: P17542;
NCBI Gene#: 6886;
NCBI Protein#: NP_001274276.1.
SDS-PAGE MW 45kd
Concentration 1.0mg/ml
Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20˚C/1 year

Application Details

Western blotting: 1:500~1:1000

Images

Western blot analysis of extracts from JK cells (Lane 2), using TAL-1 (Phospho-Ser122) Antibody #AB11814. The lane on the left is treated with antigen-specific peptide.

Background

TAL-1 is a basic helix-loop-helix transcription. Regulates differentiation and survival during hemopoiesis. Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of eryhtroid differentiation. Mutations are associated with T-cell leukemia and melanoma. Binds to the LIM domain containing protein Rhombotin-2.

Aplan P.D., Mol. Cell. Biol. 10:6426-6435(1990).
Gregory S.G., Nature 441:315-321(2006).
Chen Q., J. Exp. Med. 172:1403-1408(1990).

Published Papers

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