GABRB1(Ab-434) Antibody

Description

Product Name GABRB1(Ab-434) Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Applications WB
Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous level of total GABRB1 protein.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around aa.432~436 (R-A-S-Q-L) derived from Human GABRB1.
Target Name GABRB1
Alternative Names GABA(A) receptor; GABA(A)R beta-1; GBRB1; GABA-RB;
Accession No. Swiss-Prot: P18505
NCBI Protein: NP_000803.2
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 54kd
Western blotting: 1:500~1:1000

Images

Western blot analysis of extracts from PC12 cells using GABRB1(Ab-434) Antibody #AB21205 and the same antibody preincubated with blocking peptide.

Background

The gamma-aminobutyric acid (GABA) A receptor is a multisubunit chloride channel that mediates the fastest inhibitory synaptic transmission in the central nervous system. This gene encodes GABA A receptor, beta 1 subunit. It is mapped to chromosome 4p12 in a cluster comprised of genes encoding a 4, a 2 and gamma 1 subunits of the GABA A receptor. Alteration of this gene is implicated in the pathogenetics of schizophrenia.

Collins AL, et al. (2006) Neurogenetics ;7(3):167-174.
Ma DQ, et al. (2005) Am J Hum Genet ;77(3):377-388.
Edenberg HJ, et al. (2004) Am J Hum Genet ;74(4):705-714.

Published Papers

let us know

Customer Reviews and Rankings

No comment