JAK2 (Phospho-Tyr570) Antibody

Description

Product Name JAK2 (Phospho-Tyr570) Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Applications WB
Species Reactivity Hu
Specificity The antibody detects endogenous levels of JAK2 only when phosphorylated at tyrosine 750.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around phosphorylation site of tyrosine 570(G-D-Y(p)-G-Q) derived from Human JAK2 .
Target Name JAK2
Modification Phospho-Tyr570
Alternative Names JAK2; Janus kinase 2; kinase Jak2;
Accession No. Swiss-Prot#: O60674;
NCBI Gene#: 3717;
NCBI Protein#: NP_004963.1.
SDS-PAGE MW 125kd
Concentration 1.0mg/ml
Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20˚C/1 year

Application Details

Western blotting: 1:500~1:1000

Images

Western blot analysis of extracts from JK cells (Lane 2), using JAK2 (Phospho-Tyr570) Antibody #AB11663. The lane on the left is treated with antigen-specific peptide.

Background

Plays a role in leptin signaling and control of body weight.

Saltzman A., Biochem. Biophys. Res. Commun. 246:627-633(1998).
Dalal I., Blood 91:844-851(1998).
Peeters P., Blood 90:2535-2540(1997).

Published Papers

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