Kv2.1 (Phospho-Ser805) Antibody

Description

Product Name Kv2.1 (Phospho-Ser805) Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Applications WB
Species Reactivity Hu
Specificity The antibody detects endogenous level of Kv2.1 only when phosphorylated at serine 805.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around phosphorylation site of serine805(P-T-S(p)-P-K) derived from Human Kv2.1 .
Target Name Kv2.1
Modification Phospho-Ser805
Alternative Names DRK1; KCB1; KCNB1; Potassium channel Kv2.1; Potassium voltage-gated channel subfamily B member 1
Accession No. Swiss-Prot#: Q14721;
NCBI Gene#: 2745;
NCBI Protein#: NP_004966.1
SDS-PAGE MW 96kd
Concentration 1.0mg/ml
Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20˚C/1 year

Application Details

Western blotting: 1:500~1:1000

Images

Western blot analysis of extracts from K562 cells treated with TNF using Phospho-Kv2.1 (Ser805) antibody #AB11923.The lane on the right is treated with the antigen-specific peptide.

Background

Mediates the voltage-dependent potassium ion permeability of excitable membranes. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient.

McCord MC, Aizenman E (2013)Proc Natl Acad Sci U S A 110, 13988-93 . Norris CA, et al. (2012) J Neurosci 32, 8865-70 . Cerda O, Trimmer JS (2011)J Biol Chem 286, 28738-48 .

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