FHL2 Antibody

Description

Product Name FHL2 Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Applications WB
Species Reactivity Hu Ms
Specificity The antibody detects endogenous level of total FHL2 protein.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around aa.16~28 (I-L-R-E-E) derived from Human FHL2.
Target Name FHL2
Alternative Names SLIM3; AAG11; FHL-2; DRAL; aging-associated gene 11
Accession No. Swiss-Prot: Q14192 NCBI Protein: NP_001034581.1
SDS-PAGE MW 32kd
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C

Application Details

Western blotting: 1:500～1:1000

Images

Western blot analysis of extracts from mouse brain tissue using FLH2 Antibody #AB21692.

Background

May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation.

Genini M., Schwalbe P., Scholl F.A., Remppis A., Mattei M.-G., Schaefer B.W.DNA Cell Biol. 16:433-442(1997)

Tanahashi H., Tabira T.Hum. Mol. Genet. 9:2281-2289(2000)

Published Papers

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