DR5 Monoclonal Antibody

Description

Product Name DR5 Monoclonal Antibody
Host Species Mouse
Clonality Monoclonal
Clone No. 7F4-F8-G11
Isotype IgG1
Purification Affinity purified
Applications WB ICC
Species Reactivity Hu Ms
Specificity This antibody detects endogenous levels of TNFRSF10B and does not cross-react with related proteins.
Immunogen Type Recombinant Protein
Immunogen Description Purified recombinant human TNFRSF10B protein fragments expressed in E.coli.
Target Name DR5
Alternative Names Fas like protein; Apoptosis inducing protein TRICK2A/2B; Apoptosis inducing receptor TRAIL R2; CD 262; CD262; CD262 antigen; Cytotoxic TRAIL receptor 2; Death domain containing receptor for TRAIL/Apo 2L; Death domain containing receptor for TRAIL/Apo2L;
Accession No. Uniprot: O14763
Gene ID: 8795
SDS-PAGE MW 48kd
Formulation Purified mouse monoclonal in PBS(pH 7.4) containing with 0.02% sodium azide,0.1mg/mlBSA and 50% glycerol.
Storage store at -20˚C

Application Details

Western blotting: 1:500-1:2000

Immunocytochemistry: 1:100

Images

Immunocytochemistry of HeLa cells fixed by Paraformaldehyde and using anti-TNFRSF10B antibody diluted 1:100.
Western blot detection of TNFRSF10B antibody in Mouse kindey,Mouse brain,HCT116 and Hela cell lysates using TNFRSF10B antibody (1:500-1:2000 diluted).Predicted band size:40/48KDa.Observed band size:40/48KDa.

Background

Receptor for the cytotoxic ligand TNFSF10/TRAIL.The adapter molecule FADD recruits caspase-8 to the activated receptor.The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B.Essential for ER stress-induced apoptosis.

Published Papers

let us know

Customer Reviews and Rankings

No comment