CBR1 Monoclonal Antibody

Description

Product Name CBR1 Monoclonal Antibody
Host Species Mouse
Clonality Monoclonal
Clone No. 2C9-B12-C4
Isotype IgG1
Purification Affinity purified
Applications WB ICC
Species Reactivity Hu
Specificity This antibody detects endogenous levels of CBR1,and does not cross-react with related proteins.
Immunogen Type Recombinant Protein
Immunogen Description Purified recombinant human CBR1 protein fragments expressed in E.coli
Target Name CBR1
Alternative Names 15 hydroxyprostaglandin dehydrogenase [NADP+]; 15-hydroxyprostaglandin dehydrogenase [NADP+]; Carbonyl reductase [NADPH] 1; Carbonyl Reductase 1; CBR 1; CBR1; CBR1_HUMAN; CRN; NADPH dependent carbonyl reductase 1; NADPH-dependent carbonyl reductase 1;
Accession No. Uniprot: P16152
Gene ID: 873
SDS-PAGE MW 30kd
Formulation Purified mouse monoclonal in PBS(pH 7.4)containing with 0.2% sodium azide,50% glycerol.
Storage store at -20˚C

Application Details

Western blotting: 1:1000

Immunocytochemistry: 1:100

Images

Immunocytochemistry stain of Hela using CBR1 antibody (1:100).
Western blot detection of CBR1 in Hela,A431 & MDA-MB-468 cell lysates using CBR1 antibody(1:1000 diluted).Predicted band size:30KDa,Observed band size:30KDa.

Background

NADPH-dependent reductase with broad substrate specificity.Catalyzes the reduction of a wide variety of carbonyl compounds including quinones,prostaglandins, menadione,plus various xenobiotics.Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha.Can bind glutathione,which explains its higher affinity for glutathione-conjugated substrates.Catalyzes the reduction of S-nitrosoglutathione.

Published Papers

let us know

Customer Reviews and Rankings

No comment