PP1C Monoclonal Antibody

Description

Product Name PP1C Monoclonal Antibody
Host Species Mouse
Clonality Monoclonal
Clone No. 2F2-A3-H10
Isotype IgG2b
Purification Affinity purified
Applications WB
Species Reactivity Hu
Specificity This antibody detects endogenous levels of PPP1CC and does not cross-react with related proteins.
Immunogen Type Recombinant Protein
Immunogen Description Purified recombinant human PPP1CC protein fragments expressed in E.coli.
Target Name PP1C
Alternative Names EC 3.1.3.16; PP 1G; PP-1G; PP1G; PP1G_HUMAN; PP1gamma; PPP 1G; PPP1CC; PPP1CC protein; PPP1G; Protein phosphatase 1 catalytic subunit gamma isoform; Protein phosphatase 1C catalytic subunit; Protein phosphatase 1C subunit
Accession No. Uniprot: P36873
Gene ID: 5501
SDS-PAGE MW 38kd
Formulation Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine(pH 7.4,150 mM NaCl)with 0.2% sodium azide,0.1mg/mlBSA and 50% glycerol.
Storage store at -20˚C

Application Details

Western blotting: 1:500

Images

Western blot detection of PPP1CC antibody in Hela,293T and Jurkat cell lysates using PPP1CC antibody (1:500 diluted).Predicted band size:38KDa.Observed band size:38KDa.

Background

Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets.Protein phosphatase 1(PP1)is essential for cell division,and participates in the regulation of glycogen metabolism,muscle contractility and protein synthesis.Dephosphorylates RPS6KB1.Involved in regulation of ionic conductances and long-term synaptic plasticity.May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca2+/calmodulin dependent protein kinase II.Component of the PTW/PP1 phosphatase complex,which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase.

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