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Mouse anti-Human CD8, Biotin Conjugated mAbAB28030

  Catalog No. Package Size Price
AB28030-1 50 Tests $279.00

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Description
  • Product Name Mouse anti-Human CD8, Biotin Conjugated mAb
  • Host Species Mouse
  • Clonality Monoclonal
  • Clone No. COV8
  • Isotype IgG1
  • Applications FC
  • Species Reactivity Hu
  • Conjugates Biotin
  • Target Name CD8
  • Formulation Phosphate-buffered solution, pH 7.4, containing 0.09% sodium azide and 0.2% (w/v) BSA
  • Storage Store at 4°C. DO NOT FREEZE. LIGHT SENSITIVE MATERIAL.
Application Details

Vol.per.Test: 10 μl/Test

Notice: This reagent has been pre-diluted for use at recommended volume per test in flow cytometry analysis. Typically add 10ul of this reagent to 100μl of experimental sample with 1 X 106 cells per test. Please refer to the detailed protocol when you perform a test.

Images
  • Mouse anti-Human CD8, Biotin Conjugated mAb - Absci

    Human peripheral blood lymphocytes analyzed with Biotin CD8 mAb, followed by Sav-PE

Background

 COV8 reacts with the 32 kDa a chain of CD8. This molecule is expressed on the T suppressor/cytotoxic cell population (which comprises about 1/3 of the peripheral blood T lymphocytes total population) and with most of thymocytes, as well as a subset of NK cells. CD8 expresses as either a heterodimer with the CD8b chain (CD8ab) or as a homodimer (CD8aa or CD8bb). CD8 acts as a co-receptor with MHC Class I restricted TCRs in antigen recognition. CD8 function is important for positive selection of MHC Class I restricted CD8+ T cells during T cell development.

* Ratio of CD4 and CD8 is important for monitor of HIV infection.
 
1. Engleman EG et al. (1981) J Exp Med 153: 193-198.
2. Haynes, B et al. (1986) Leukocyte Typing II: Human T lymphocytes. New York: Sprimger-Verlag; 3-30.
3. Parnes, JR. et al. (1989). Adv. Immunol. 44,256-311.
4. Bikah G. et al. (1996). Science  274:1906.
    Please let us know if you have published research using #AB28030 so that we can cite your reference.
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    Protocol
    Browsing historyclear
    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  


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