PGC-1 alpha Monoclonal Antibody

Description

Product Name PGC-1 alpha Monoclonal Antibody
Host Species Mouse
Clonality Monoclonal
Purification Affinity-chromatography
Applications E WB
Species Reactivity Hu
Specificity PGC-1alpha antibody detects endogenous levels of total PGC-1alpha
Immunogen Type Recombinant protein
Immunogen Description Purified recombinant fragment of human PGC-1alpha expressed in E. Coli
Target Name PGC-1 alpha
Alternative Names PPARGC1A; LEM6; PGC1; PGC1A; PGC-1v; PPARGC1; PGC-1(alpha)
Accession No. Swiss-Prot#: Q9UBK2
SDS-PAGE MW 91KD
Concentration 1.0mg/ml
Formulation Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20 °C.Stable for 12 months from date of receipt
Storage Store at -20°C/1 year

Application Details

ELISA: 1:10000

WB: 1:500 - 1:2000

Images

Western blot analysis using PGC-1alpha mAb against human PGC-1alpha (AA: 570-798) recombinant protein. (Expected MW is 70 kDa)

Background

The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPAR gamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between external physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determination. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity.

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