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  Catalog No. Package Size Price
AB21130-1 50ul $189.00
AB21130-2 100ul $279.00
AB21130-4 25ul $119.00

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  • Product Name AMPKα1(Ab-496)Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Applications WB IHC
  • Species Reactivity Hu
  • Specificity The antibody detects endogenous level of total AMPKa1 protein.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around aa.494~498 (S-G-S-V-S) derived from Human AMPKα1.
  • Target Name AMPKa1
  • Alternative Names AAPK1; AMPK alpha-1 chain; AMPK-alpha1; HMG-CoA redustase kinase; PRKAA1
  • Accession No. Swiss-Prot: Q13131/P54646
    NCBI Protein: NP_006242.5
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 63kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100

  • AMPKα1(Ab-496)Antibody - Absci

    Western blot analysis of extracts from 293 cells using AMPKα1 (Ab-496)Antibody #AB21130.

  • AMPKα1(Ab-496)Antibody - Absci

    Immunohistochemical analysis of paraffin-embedded human colon carcinoma tissue using AMPKα1 (Ab-496)Antibody #AB21130 (left) or the same antibody preincubated with blocking peptide (right).


Responsible for the regulation of fatty acid synthesis by phosphorylation of acetyl-CoA carboxylase. It also regulates cholesterol synthesis via phosphorylation and inactivation of hormone-sensitive lipase and hydroxymethylglutaryl-CoA reductase. Appears to act as a metabolic stress-sensing protein kinase switching off biosynthetic pathways when cellular ATP levels are depleted and when 5'-AMP rises in response to fuel limitation and/or hypoxia. This is a catalytic subunit.

Kim JE, et al. (2005) J Proteome Res. 4(4): 1339-1346.
Woods A, et al. (2003) J Biol Chem. 278(31): 28434-28442.

    Please let us know if you have published research using #AB21130 so that we can cite your reference.
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    Browsing historyclear
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  

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