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CREB(Phospho-Ser142) AntibodyAB11300

  Catalog No. Package Size Price
AB11300-1 50ul $189.00
AB11300-2 100ul $279.00
AB11300-4 25ul $119.00

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Description
  • Product Name CREB(Phospho-Ser142) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
  • Applications WB IHC
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous level of CREB only when phosphorylated at serine142.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around phosphorylation site of serine 142(D-L-S(p)-S-D) derived from Human CREB.
  • Target Name CREB
  • Modification Phospho-Ser142
  • Alternative Names CREB
  • Accession No. Swiss-Prot: P16220; NCBI Gene ID: 1385; NCBI mRNA: NM_004379.3; NCBI Protein: NP_004370.1
  • SDS-PAGE MW 43KD
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C
Application Details

 Predicted MW: 43kd
 Immunohistochemistry: 1:50~1:100 

Images
  • CREB(Phospho-Ser142) Antibody - Absci

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using CREB (Phospho-Ser142) Antibody (#AB11300).

  • CREB(Phospho-Ser142) Antibody - Absci

    Western blot analysis of extracts from 293 cells, treated with calf intestinal phosphatase (CIP), using CREB(Phospho-Ser142) Antibody #AB11300.

Background

 Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.

    Please let us know if you have published research using #AB11300 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  


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