FOXP3 Monoclonal Antibody

Description

Product Name FOXP3 Monoclonal Antibody
Host Species Mouse
Clonality Monoclonal
Purification Affinity-chromatography
Applications E WB
Species Reactivity Hu
Specificity FOXP3 antibody detects endogenous levels of total FOXP3
Immunogen Type Peptide
Immunogen Description Synthetic peptide conjugated to KLH derived from Human Heme Oxygenase 1.
Target Name FOXP3
Alternative Names JM2; AIID; IPEX; PIDX; XPID; DIETER; MGC141961; MGC141963; FOXP3
Accession No. Swiss-Prot#: Q9BZS1
SDS-PAGE MW 47.2KD
Concentration 1.0mg/ml
Formulation Mouse IgG1 in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.Store at -20°C. Stable for 12 months from date of receipt.
Storage Store at -20°C/1 year

Application Details

ELISA 1/10000

WB 1/500 - 1/2000

Images

Figure 1: Western blot analysis using FOXP3 mAb against FOXP3(AA: 2-193)-hIgGFc transfected HEK293 cell.

Background

FOXP3 (a 431 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, at low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.

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