NFκB-p105(Phospho-Ser893) Antibody

Description

Product Name NFκB-p105(Phospho-Ser893) Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Applications IHC IF
Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous level of total NFÎºB-p105 protein.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around aa.891~895 (A-S-S-P-V) derived from Human NFκB-p105.
Target Name NFκB-p105
Modification Phospho-Ser893
Alternative Names KBF1; NF-kB1; NFkappaB
Accession No. Swiss-Prot#: P19838; NCBI Gene#: 4790
SDS-PAGE MW 120kd
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C

Application Details

Immunohistochemistry：1:50~1:100
Immunofluorescence：1:100~1:200

Images

Immunofluorescence staining of methanol-fixed HeLa cells using NF-κB p105 (phospho-Ser893) antibody (#AB11018 Red).
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NF-κB p105 (phospho-Ser893) antibody (#AB11018).

Background

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.

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