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Tau(Ab-214) AntibodyAB21098

  Catalog No. Package Size Price
AB21098-1 50ul $189.00
AB21098-2 100ul $279.00
AB21098-4 25ul $119.00

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Description
  • Product Name Tau(Ab-214) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Applications IF
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous level of total Tau protein.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around aa.212~216 (T-P-S-L-P) derived from Human Tau.
  • Target Name Tau
  • Alternative Names MAPT; MTAPT; MTBT1; Neurofibrillary tangle protein; PHF-tau
  • Accession No. Swiss-Prot: P10636
    NCBI Protein: NP_001116538.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 48 62 78 kd
Immunofluorescence: 1:100~1:200

Images
  • Tau(Ab-214) Antibody - Absci

    Immunofluorescence staining of methanol-fixed Hela cells using Tau(Ab-214) Antibody #AB21098.

Background
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.

Smet C, et al. (2005) FEBS Lett; 579(19): 4159-64.
Puig B, et al. (2005) Acta Neuropathol (Berl).
Gvtz J, et al. (2001) Science; 293(5534): 1491-5.
Illenberger S, et al. (1998) Mol Biol Cell; 9(6): 1495-512.
    Please let us know if you have published research using #AB21098 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  


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