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NFkB-p100(Ab-870) AntibodyAB21016

  Catalog No. Package Size Price
AB21016-1 50ul $189.00
AB21016-2 100ul $279.00
AB21016-4 25ul $119.00

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Description
  • Product Name NFkB-p100(Ab-870) Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Purification Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
  • Applications WB IHC
  • Species Reactivity Hu Ms Rt
  • Specificity The antibody detects endogenous level of total NFkB-p100 protein.
  • Immunogen Type Peptide-KLH
  • Immunogen Description Peptide sequence around aa.868~872 (Y-G-S-Q-S) derived from Human NFkB-p100.
  • Target Name NFkB-p100
  • Alternative Names DNA-binding factor KBF2; H2TF1; Lymphocyte translocation chromosome 10; Lyt10; NFKB2
  • Accession No. Swiss-Prot: Q00653
    NCBI Protein: NP_001070961.1
  • Concentration 1.0mg/ml
  • Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.
Application Details

Predicted MW: 120 kd
Western blotting: 1:500~1:1000
Immunohistochemistry: 1:50~1:100
 

Images
  • NFkB-p100(Ab-870) Antibody - Absci

    Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using NFkB-p100(Ab-870) Antibody #AB21016(left) or the same antibody preincubated with blocking peptide(right).

  • NFkB-p100(Ab-870) Antibody - Absci

    Western blot analysis of extracts from HL60 cells using NFkB-p100(Ab-870) Antibody #AB21016.

Background

NFKB has been detected in numerous cell types that express cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NFKB is activated by a wide variety of stimuli such as cytokines, oxidant-free radicals, inhaled particles, ultraviolet irradiation, and bacterial or viral products. Inappropriate activation of NF-kappa-B has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-kappa-B has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth.

Qu Z, et al. (2004) J Biol Chem; 279(43): 44563-72.
Xiao G, et al. (2001) J Biol Chem 7(2): 401-9.
 

    Please let us know if you have published research using #AB21016 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  


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