Predicted MW: 125kd
Western blotting: 1:500~1:1000
Immunofluorescence: 1:100~1:200
Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity.
Parsons, J.T. et al. (2000) Oncogene 19, 5606-5613
Schaller, M.D. et al. (1994) Mol. Cell. Biol. 14, 1680-1688.
Cobb, B.S. et al. (1994) Mol. Cell. Biol. 14, 147-155.
Chen, H.C. et al. (1996) J. Biol. Chem. 271, 26329-26334.
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