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Smad2(Phospho-Ser467) AntibodyAB11322

Catalog No.	Package Size	Price
AB11322-1	50ul	$189.00
AB11322-2	100ul	$279.00
AB11322-4	25ul	$119.00

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Description

Product Name Smad2(Phospho-Ser467) Antibody
Host Species Rabbit
Clonality Polyclonal
Purification Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Applications WB
Species Reactivity Hu Ms Rt
Specificity The antibody detects endogenous level of Smad2 only when phosphorylated at serine 467.
Immunogen Type Peptide-KLH
Immunogen Description Peptide sequence around phosphorylation site of serine 467 (C-S-S-M-S(p)) derived from Human Smad2.
Target Name Smad2
Modification Phospho-Ser467
Alternative Names JV18-1; MADH2; MADR2; Mad-related protein 2; Mothers against DPP homolog 2
Accession No. Swiss-Prot: Q15796
NCBI Protein: NP _001003652.1
Concentration 1.0mg/ml
Formulation Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Application Details

Predicted MW: 60kd
Western blotting: 1:500~1:1000

Images

Western blot analysis of extracts from Hela cells untreated or treated with PMA using Smad2(Phospho-Ser467) Antibody #AB11322.

Background

Transcriptional modulator activated by TGF-beta and activin type 1 receptor kinase. SMAD2 is a receptor-regulated SMAD (R-SMAD). May act as a tumor suppressor in colorectal carcinoma.

Sang Gyun Kim et al. (2004) Mol Biol Cell. February; 15(2): 420

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