Predicted MW: 100kd
Western blotting: 1:500~1:1000
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist.
Cull-Candy, S. et al. (2006) Curr. Opin. Neurobiol. 16, 288-297.
Hanley JG, et al. (2002) Neuron. 34(1): 53-67
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