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NOTCH2 Rabbit Polyclonal AntibodyAB53052

  Catalog No. Package Size Price
AB53052-1 50ul $309.00
AB53052-2 100ul $439.00

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Description
  • Product Name NOTCH2 Rabbit Polyclonal Antibody
  • Host Species Rabbit
  • Clonality Polyclonal
  • Isotype IgG
  • Purification Affinity purification
  • Applications WB,IF
  • Species Reactivity Human,Mouse,Rat
  • Immunogen Description Recombinant fusion protein of human NOTCH2 (NP_077719.2).
  • Alternative Names NOTCH2;AGS2;HJCYS;hN2;notch 2
  • Accession No. Uniprot:Q04721
    GeneID:4853
  • Calculated MW 265kDa
  • SDS-PAGE MW 120kDa
Application Details

 WB 1:500 - 1:2000
IF 1:50 - 1:200

Images
  • NOTCH2 Rabbit Polyclonal Antibody - Absci

    Western blot analysis of extracts of various cell lines, using NOTCH2 antibody.

  • NOTCH2 Rabbit Polyclonal Antibody - Absci

    Immunofluorescence analysis of L929 cells using NOTCH2 antibody.

Background

 This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.

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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  


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