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phospho-Akt1 (Phospho-Ser479) Antibody12891

  Catalog No. Package Size Price
12891-1 50ul $189.00
12891-2 100ul $279.00

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Description
  • Product Name phospho-Akt1 (Phospho-Ser479) Antibody
  • Brief Description Rabbit Polyclonal
  • Host Species Rabbit
  • Clonality Polyclonal
  • Applications WB
  • Species Reactivity Hu Ms Rt
  • Specificity phospho-Akt1 (Ser479) Antibody detects endogenous levels of Akt1 only when phosphorylated at Ser479
  • Immunogen Type Peptide-KLH
  • Immunogen Description A synthesized peptide derived from human phospho-Akt1 (Phospho-Ser479)
  • Alternative Names AKT 1 antibody AKT antibody AKT1 antibody AKT1_HUMAN antibody MGC99656 antibody PKB antibody PKB-ALPHA antibody PRKBA antibody Protein Kinase B Alpha antibody Protein kinase B antibody Proto-oncogene c-Akt antibody RAC Alpha antibody RAC antibody RAC-alpha serine threonine-protein kinase antibody RAC-PK-alpha antibody
  • Accession No. Swiss-Prot#:P31749
    NCBI Gene ID207
  • Calculated MW 60
  • Concentration 1.0mg mL
  • Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) pH 7.4 150mM NaCl 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20˚C
Application Details

WB dilution:1:1000

Images
  • phospho-Akt1 (Phospho-Ser479) Antibody - Absci

    Western blot analysis phospho-Akt1 (Phospho-Ser479) using Jurkat whole cell lysates

Product Description
Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation (By similarity). General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. The activated form can suppress FoxO gene transcription and promote cell cycle progression. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  


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