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EPHA2 (Phospho-Tyr575) Antibody12884

  Catalog No. Package Size Price
12884-1 50ul $189.00
12884-2 100ul $279.00

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Description
  • Product Name EPHA2 (Phospho-Tyr575) Antibody
  • Brief Description Rabbit Polyclonal
  • Host Species Rabbit
  • Clonality Polyclonal
  • Applications WB
  • Species Reactivity Hu Ms Rt
  • Specificity EPHA2 (Phospho-Y575) Antibody detects endogenous levels of EPHA2 only when phosphorylated at Y575
  • Immunogen Type Peptide-KLH
  • Immunogen Description A synthesized peptide derived from human EPHA2 (Phospho-Tyr575)
  • Alternative Names ARCC2 antibody AW545284 antibody CTPA antibody CTPP1 antibody CTRCT6 antibody EC 2.7.10.1 antibody Eck antibody Eph receptor A2 antibody EPHA2 antibody EPHA2_HUMAN antibody Ephrin receptor antibody Ephrin receptor EphA2 antibody Ephrin type A receptor 2 antibody Ephrin type-A receptor 2 antibody Epithelial cell kinase antibody Epithelial cell receptor protein tyrosine kinase antibody Myk 2 antibody Myk2 antibody Sek 2 antibody Sek2 antibody Soluble EPHA2 variant 1 antibody Tyrosine protein kinase receptor ECK antibody Tyrosine-protein kinase receptor ECK antibody Tyrosine-protein kinase receptor MPK-5 antibody Tyrosine-protein kinase receptor SEK-2 antibody
  • Accession No. Swiss-Prot#:P29317
    NCBI Gene ID1969
  • Calculated MW 125
  • Concentration 1.0mg mL
  • Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) pH 7.4 150mM NaCl 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20˚C
Application Details

WB dilution:1:1000

Images
  • EPHA2 (Phospho-Tyr575) Antibody - Absci

    Western blot analysis EPHA2 (Phospho-Tyr575) using mouse brain whole cell lysates

Product Description
The Eph receptors are the largest known family of receptor tyrosine kinases (RTKs). They can be divided into two groups based on sequence similarity and on their preference for a subset of ligands: EphA receptors bind to a glycosylphosphatidylinositol-anchored ephrin A ligand; EphB receptors bind to ephrin B proteins that have a transmembrane and cytoplasmic domain (1,2). Research studies have shown that Eph receptors and ligands may be involved in many diseases including cancer (3). Both ephrin A and B ligands have dual functions. As RTK ligands, ephrins stimulate the kinase activity of Eph receptors and activate signaling pathways in receptor-expressing cells. The ephrin extracellular domain is sufficient for this function as long as it is clustered (4). The second function of ephrins has been described as "reverse signaling", whereby the cytoplasmic domain becomes tyrosine phosphorylated, allowing interactions with other proteins that may activate signaling pathways in the ligand-expressing cells (5). Various stimuli can induce tyrosine phosphorylation of ephrin B, including binding to EphB receptors, activation of Src kinase, and stimulation by PDGF and FGF (6). Tyr324 and Tyr327 have been identified as major phosphorylation sites of ephrin B1 in vivo (7).
    Please let us know if you have published research using #12884 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  


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