SpecificityPhospho-LATS2 (Y286) Antibody detects endogenous levels of LATS2 only when phosphorylated at Y286
Immunogen TypePeptide-KLH
Immunogen DescriptionA synthesized peptide derived from human LATS2 (Phospho-Tyr286)
Alternative NamesFLJ13161 antibody
Kinase phosphorylated during mitosis protein antibody
KPM antibody
Large tumor suppressor homolog 2 antibody
Large tumor suppressor homolog 2 Drosophila antibody
Large tumor suppressor kinase 2 antibody
LATS large tumor suppressor Drosophila homolog 2 antibody
LATS large tumor suppressor homolog 2 antibody
Lats2 antibody
LATS2_HUMAN antibody
Serine threonine kinase kpm antibody
Serine threonine protein kinase kpm antibody
Serine threonine-protein kinase kpm antibody
Serine threonine-protein kinase LATS2 antibody
Warts like kinase antibody
Warts-like kinase antibody
Accession No.Swiss-Prot#:Q9NRM7 NCBI Gene ID26524
Calculated MW150
Concentration1.0mg mL
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) pH 7.4 150mM NaCl 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C
Application Details
WB dilution:1:1000
Images
Western blot analysis LATS2 (Phospho-Tyr286) using A431 whole cell lysates
Product Description
LATS2 is an AGC kinase of the NDR family of kinases. It is a tumor suppressor of the LATS family, and plays a critical role in centrosome duplication, maintenance of mitotic fidelity, and genomic stability (1). LATS2 inhibits cell growth at the G1,S transition by down-regulating cyclin E,CDK2 kinase activity (2). It also plays an important role in regulation of the Hippo pathway, a pathway that is important in controlling organ size and tumor progression by regulating cellular proliferation and promoting apoptosis (3,4,5)?
Yes
