SpecificityPhospho-RUNX3(T209) Antibody detects endogenous levels of RUNX3 only when phosphorylated at T209
Immunogen TypePeptide-KLH
Immunogen DescriptionA synthesized peptide derived from human RUNX3(Phospho-Thr209)
Alternative NamesAcute myeloid leukemia 2 protein antibody
Acute myeloid leukemia gene 2 antibody
AML 2 antibody
AML2 antibody
CBF alpha 3 antibody
CBF-alpha-3 antibody
CBFA 3 antibody
CBFA3 antibody
Core binding factor alpha 3 subunit antibody
core binding factor antibody
Core binding factor runt domain alpha subunit 3 antibody
Core binding factor subunit alpha 3 antibody
core-binding factor antibody
Core-binding factor subunit alpha-3 antibody
Oncogene AML 2 antibody
Oncogene AML-2 antibody
PEA2 alpha C antibody
PEA2-alpha C antibody
PEBP2 alpha C antibody
PEBP2-alpha C antibody
Pebp2a3 antibody
PEBP2aC antibody
Polyomavirus enhancer binding protein 2 alpha C subunit antibody
Polyomavirus enhancer-binding protein 2 alpha C subunit antibody
runt domain alpha subunit 3 antibody
runt related transcription factor 3 antibody
Runt-related transcription factor 3 antibody
RUNX 3 antibody
Runx3 antibody
RUNX3_HUMAN antibody
SL3 3 enhancer factor 1 alpha C subunit antibody
SL3-3 enhancer factor 1 alpha C subun
Accession No.Swiss-Prot#:Q13761 NCBI Gene ID864
Calculated MW43-48
Concentration1.0mg mL
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) pH 7.4 150mM NaCl 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C
Application Details
WB dilution:1:1000
Images
Western blot analysis RUNX3(Phospho-Thr209) using EGF treated 293 whole cell lysates
Product Description
RUNX3,AML2 is a member of the Runt family of transcription factors. RUNX3 is important for the suppression of cell proliferation in the gastric epithelium (1), neurogenesis of the dorsal root ganglia (2), and T cell differentiation (3,4). According to the research literature, RUNX3 is found to be inactivated in more than 80% of gastric cancers and other cancer types by gene silencing or protein mislocalization (1,5,6). The tumor suppressor function of RUNX3 is exerted by forming complexes with various transcription factors, such as Smads or β-Catenin,TCF4 to regulate downstream target gene transcription (7,8). RUNX3 is also involved in caspase-3-dependent apoptosis (9). RUNX3 is normally located in the nucleus, however, in many cancer cells, RUNX3 is tyrosine phosphorylated and mislocated to the cytoplasm. The mislocation of RUNX3 abolishes its tumor suppressor function and contributes to tumorigenesis (10).
Yes
