SpecificityPhospho-MEF2C (S240) Antibody detects endogenous levels of MEF2C only when phosphorylated at S240
Immunogen TypePeptide-KLH
Immunogen DescriptionA synthesized peptide derived from human MEF2C (Phospho-Ser240)
Alternative NamesC5DELq14.3 antibody
DEL5q14.3 antibody
MADS box transcription enhancer factor 2 polypeptide C (myocyte enhancer factor 2C) antibody
MADS box transcription enhancer factor 2 polypeptide C antibody
MEF2C antibody
MEF2C_HUMAN antibody
Myocyte enhancer factor 2C antibody
Myocyte specific enhancer factor 2C antibody
Myocyte-specific enhancer factor 2C antibody
OTTHUMP00000222409 antibody
Similar to MADS box transcription enhancer factor 2 polypeptide C antibody
Accession No.Swiss-Prot#:Q06413 NCBI Gene ID4208
Calculated MW51
Concentration1.0mg mL
FormulationRabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) pH 7.4 150mM NaCl 0.02% sodium azide and 50% glycerol.
StorageStore at -20˚C
Application Details
WB dilution:1:1000
Images
Western blot analysis MEF2C (Phospho-Ser240) using 293 whole cell lysates
Product Description
Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.