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Afadin (Phospho-Ser1795) Antibody 12847

  Catalog No. Package Size Price
12847-1 50ul $189.00
12847-2 100ul $279.00

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Description
  • Product Name Afadin (Phospho-Ser1795) Antibody
  • Brief Description Rabbit Polyclonal
  • Host Species Rabbit
  • Clonality Polyclonal
  • Applications WB
  • Species Reactivity Hu Ms Rt
  • Specificity Phospho-Afadin (Ser1795) Antibody detects endogenous levels of Afadin only when phosphorylated at Ser1795
  • Immunogen Type Peptide-KLH
  • Immunogen Description A synthesized peptide derived from human Afadin (Phospho-Ser1795)
  • Alternative Names AF6 antibody AFAD_HUMAN antibody Afadin antibody ALL1-fused gene from chromosome 6 protein antibody Mllt4 antibody Protein Af-6 antibody Protein AF6 antibody
  • Accession No. Swiss-Prot#:P55196
    NCBI Gene ID4301
  • Calculated MW 205
  • Concentration 1.0mg mL
  • Formulation Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+) pH 7.4 150mM NaCl 0.02% sodium azide and 50% glycerol.
  • Storage Store at -20˚C
Application Details

WB dilution:1:1000

Images
  • Afadin (Phospho-Ser1795) Antibody  - Absci

    Western blot analysis Afadin (Phospho-Ser1795) using HeLa whole cell lysates

Product Description
In multicellular organisms, intercellular junctions play essential roles in tissue integrity and maintenance of cell polarity. Tight junctions (TJs) form a continuous barrier to fluids across the epithelium and endothelium (reviewed in 1). Adherens junctions (AJs) are dynamic structures that form cell-cell contacts linking cells into a continuous sheet (reviewed in 2). The actin filament-binding protein, Afadin, binds to nectin forming a connection to the action cytoskeleton (3). AJs are formed when nectin assembles cadherin at the cell-cell adhesion site and these junctions are then involved in the formation and maintenance of TJs (4, 5). Afadin has two splice variants: l-afadin, which is ubiquitously expressed, and s-afadin, which is expressed predominantly in neural tissue. s-Afadin is a shorter form lacking one of the three proline-rich regions found in l-afadin as well the carboxyl-terminal F-actin binding region (6). Human s-afadin is identical to AF-6, the ALL-1 fusion partner involved in acute myeloid leukemias (7). Recent work has also shown that afadin is involved in controlling the directionality of cell movement when it is localized at the leading edge of moving cells (8, 9).
    Please let us know if you have published research using #12847 so that we can cite your reference.
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    Protocol
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    Note
      Application:
    • WBWestern Blotting
    • IHCImmunohistochemistry
    • IFImmunofluorescence
    • ICCImmunocytochemistry
    • FCFlow Cytometry
    • IPImmunoprecipitation
    • EELISA
    • DBDot Blotting
    • ChIPChromatin Immunoprecipitation
    • GICAGold Immunochromatography Assay
    • NCNegative Control
      Species Reactivity:
    • HuHuman
    • MsMouse 
    • RtRat 
    • Dm Drosophila melanogaster
    • C Caenorhabditis elegans
    • MkMonkey
    • RbRabbit
    • B Bovine 
    • D Dog
    • PPig
    • HmHamster
    • ChHm Chinese Hamster 
    • ChkChicken  
    • ShpSheep  


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